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KMID : 0377619720230060579
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Korean Jungang Medical Journal
1972 Volume.23 No. 6 p.579 ~ p.584
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Masstreatment of Ascaris and Hookworm Infections with Pyrantel Pamoate (Combantrin)
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ßïÜ°àÙ/Seo, Byong-Seol
ÚÓïÒФ/ðáã°æï/Ë©ãáç´/åàÎÃÜâ/ˬá¦ôÊ/ì°ê¹î¥/Lim, Jung-Kyoo/Cho, Seung-Yull/Kang, Shin-Yong/Uh, Kwang-Bon/Kang, Se-Chul/Lee, Won-Jae
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Abstract
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The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea.
Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study.
Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively.
No side effects and no problem in drug administration were demonstrated.
It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.
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